ea0016p496 | Obesity | ECE2008
Wobser Hella
, Dorn Christoph
, Weiss Thomas
, Scholmerich Jurgen
, Hellerbrand Claus
Background: Non-alcoholic steatohepatitis (NASH) can progress to hepatic fibrosis and end-stage liver disease. Hepatic stellate cells (HSC) are the central mediators of liver fibrosis. The molecular mechanisms linking hepatic steatosis to activation of HSC, thereby promoting inflammation and fibrosis, are mainly unknown. Here, we demonstrate a novel in vitro model to study the effect of hepatic lipid accumulation on HSC.Methods and results:...